Biomarkers - Dorian Technologies

Amyloid PET

Amyloid-β deposits are characteristic of some neurodegenerative diseases associated with dementia as Alzheimer's disease. The amyloid PET is a crucial tool in the in-vivo assessment of these deposits and its evaluation has proven to strongly benefit from quantification.
DORIAN’s solution to amyloid quantification integrates traditional and innovative independent algorithms to overcome the inherent limitations of each method. This solution was validated alongside our clinical partners for all commercial tracers. The algorithms include two innovative patented methods:

ELBA: designed to capture intensity distribution patterns that are global properties of the whole brain and do not require a reference ROI.
TDR: exploits the information provided by the tracer kinetics to determine the most suitable target regions.

SPECT

The ¹²³I-Ioflupane SPECT images - commercially known as DaTSCAN or STRIASCAN -, are commonly used in the diagnostic pathway of movement disorders. To help the diagnostic evaluation, we developed a fully-automated software for computing a number of intensity or shape-based markers such as:

Padua signal density - PD
Striatal Volume - Vol
Specific Binding Ratio - SBR
Shape markers

For each marker of each lobe, the marker value will be returned along with an age-corrected percentile value. An overall, machine-learning based probabilistic assessment will also be displayed to suggest a possible prediction of evaluation, based on more than a thousand manual gravity assessments run by consensus. This will produce an automated and data-driven report. The whole process is intended to facilitate the clinical report of a ¹²³I-Ioflupane SPECT, especially in doubtful cases.